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pentobarbital will improve the stage or impact of ivosidenib by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Prevent or Use Alternate Drug. Coadministration of ivosidenib with potent CYP3A4 inducers lowered ivosidenib plasma concentrations.pentobarbital will decrease the level or influence of artemether/lumefantrine by impacting hepatic